Blar i forfatter "Rasmussen, Trude Victoria"

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    • Expression and characterization of recombinant murine integrin β3 modified to express the human platelet antigen-1a epitope 

      Rasmussen, Trude Victoria (Mastergradsoppgave; Master thesis, 2017-05-14)
      Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a condition where the mother produces alloantibodies against fetal platelets during pregnancy most commonly due to an incompatibility in the human platelet antigen (HPA)-1 system; a single amino acid polymorphism located on integrin β3 with two common variants, HPA-1a and HPA-1b. Antibody responses against HPA-1a can be formed in women who ...

    • Murine models for studying treatment, prevention and pathogenesis of FNAIT 

      Rasmussen, Trude Victoria; Ahlen, Maria Therese (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-31)
      Maternal alloimmunization to paternally inherited antigens on fetal/neonatal platelets can cause fetal/neonatal alloimmune thrombocytopenia (FNAIT) after antibody-mediated removal of platelets from the fetal circulation. The complications vary from mild bleeding symptoms to severe intracranial hemorrhage and subsequent neurological impairment or death. Studies on <i>in vivo</i> mechanisms are ...